| 초록 |
Recently, there are now widespread examples of modified HA macromers that form either covalent or physical hydrogels through crosslinking reactions such as click chemistry or supramolecular assemblies of guest-host pairs. Here, we engineered methacrylated hyaluronic acid (meHA) with peptide crosslinker to generate bio-orthogonal polymerization. Peptide cross linker is used to trigger degradation by various specific proteases. This study focuses on the microfluidic preparation of monodispersed meHA hydrogel, for which a controllable polymerization technique is proposed. The resulting hydrogel beads can be used for the culture of cells in vitro, as carriers for cells in vivo, or to deliver therapeutics in an environmentally responsive manner. |
