| 초록 |
We fabricated poly(ε-caprolactone) (PCL)-based polyurethane (PU) foam scaffold as a replacement of ear or bone with cartilage by gas foaming method. Sulfuric acid and silicone surfactant were used to form high porosity outside and inside of the PU scaffold, respectively. For the blowing agent, an aqueous gelatin solution was used. As polyol, PCL diol or triol was used to endue biocompatibility, biodegradability, low cytotoxicity, and tunable mechanical properties. PCL diol-based PU scaffold has flexible and ductile properties, whereas PCL triol-based PU scaffold has rigid properties. Due to its swelling properties, customized PU scaffold such as ear and bone shape was simply produced by using organ shape silicone molds. Since glue or solvent was not needed to connect PU scaffolds with different mechanical properties, PCL triol-based PU scaffold connected with PCL diol-based PU scaffold (corresponding to bone and cartilage, respectively) was easily made. |
