| 학회 |
한국화학공학회 |
| 학술대회 |
2007년 가을 (10/26 ~ 10/27, 한국과학기술원) |
| 권호 |
13권 2호, p.1341 |
| 발표분야 |
고분자 |
| 제목 |
Core-shell(Poly(D,L-lactide-co-glycolide)/(Ethyl 2-cyanoacrylate) ) structured microsphere for sustained drug delivery |
| 초록 |
Monodispersed core-shell structured microcapsules by a Shirasu porous glass (SPG) membrane emulsification technique were prepared to reduce the initial burst release. Solution mixtures with different ratio of Poly(D,L-lactide-co-glycolide) (PLGA) polymers, ethyl 2-cyanoacrylate (E2CA) monomers and Doxorubicin were permeated through the SPG membrane with 1.9m pore size into continuous water phase with sodium lauryl sulfate as surfactant by applying a pressure. Anionic interfacial polymerization of E2CA was started at the O/W interface by OH− initiation. The prepared microcapsules were monodisperse and from 1.4m to 1.9m particle size. The morphology and core-sehll structure of microcapsules were investigated by a field emission scanning electron microscope (FE-SEM) and transmission electron microscopy (TEM). Our study provided precedented control of microsphere size and might allow development of advanced controlled-release delivery systems. PLGA/E2CA mass ratio of 50:50 was found to be the optimal ratio giving the best release rate. |
| 저자 |
이상혁, 최성욱, 김중현
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| 소속 |
연세대 |
| 키워드 |
core-shell; monodisperse; Poly(D; L-lactide-co-glycolide); Ethyl 2 -cyanoacrylate; SPG membrane emulsification; doxorubicin
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| E-Mail |
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| 원문파일 |
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