| 초록 |
We fabricated size-controllable aptamer conjugated ultrathin carboxylated polypyrrole nanotubes (A-UCPPyNTs) as transducers in 17ß-estradiol field-effect transistor (FET) biosensors. They were manufactured via a self-degradation method with several different conditions to control the diameter of the nanotubes. In order to targeting 17ß-estradiol, the binding aptamers were immobilized through covalent bonding on its surface area. The reslting A-UCPPyNT FET biosensor demonstrated p-type behavior with outstanding electrical conductivity. The smaller diameter (40 nm) of UCPPyNTs contributed to the biosensor's enhanced performance by generating a larger surface area, thereby increasing the number of conjugated binding aptamers. In conclusion, the A-UCPPyNT FET biosensor proved extremely high sensitivity (~1 fM) toward 17ß-estradiol and unique selectivity to the 17ß-estradiol molecule, in addition to the outstanding reusability and the long-term storage stability. |
