| 초록 |
Owing to the development of a drug delivery system (DDS) based on enhanced permeation and retention (EPR) effect, polymer nanoparticles can selectively accumulate into the tumors. Except for cancers, however, DDS and EPR effects cannot be applied to other diseases such as inflammatory diseases because nanoparticles cannot be directly delivered into the disease areas. To achieve this problem, polymer drugs were designed by amino acids (cysteine, ornithine, and arginine), and the metabolism of amino acids in the disease areas was controlled to treat the target diseases. These polymer drugs would sustainably release the amino acids and control the tissue distribution by the biodegradation of the polymer chains in the intestines. The therapeutic effects on non-alcoholic steatohepatitis, acute liver injury, and cancers by amino acid-based polymer assembling drugs will be shown in this presentation. |
