| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
Interface-Cross-linked Micelles of Poly(D,L-lactide)-b-poly(furfuryl methacrylate)-b-poly(N-acryloylmorpholine) for Near-infrared-triggered Drug Delivery Application |
| 초록 |
We report a NIR-responsive interface cross-linked (ICL) micelles prepared by usingthe Diels-alder click creaction between poly(D,L-lactide)-b-poly(furfurylmethacrylate)-b-poly(N-acryloylmorpholine) (PLA-b-PFMA-b-PNAM) triblockcopolymers and a diselenide cross-linker, bis(maleimidoethyl)3,3’-diselanediyldipropionoate (BMEDSeDP). PLA-b-PFMA-b-PNAM was synthesized bythe sequential RAFT polymerization of FMA and NAM using PLA-macro‐chaintransfer agent (PLA-CTA) as a macro-initiator. The release of DOX from the ICLmicelles was suppressed (ca. 11% in 60 h) under physiological conditions (pH7.4), indicating that the interfacial cross-linking protected the drug release from the micelles. The in vitro analysis indicated that the ICL was not cytotoxic against normal HFF-1 cells (non-cancerous), while higher antitumoractivity towards HeLa cells were exhibited by DOX-loaded ICL micelles. The developed ICL micelles would provide a promising robust anticancer drug delivery system. |
| 저자 |
주수빈, Sonyabapu Yadav, 조이준, 박찬, 오철웅, 임권택
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| 소속 |
부경대 |
| 키워드 |
NIR; ICL micelles; DOX; DDS
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| E-Mail |
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