| 초록 |
Injectable insulin is the most popular treatment for curing diabetes mellitus. However, patients have lower adherence to the glycemic management using injectable insulin due to portal-peripheral insulin gradient, pain and needle phobia. Therefore, oral insulin formulations have been developed for patient’s convenience and closeness. To overcome the limitations in this study, we newly developed an oral insulin formulation that can interact with lactoferrin receptors (Lf-R) on the gastrointestinal barriers. For this purpose, we prepared lactoferrin (Lf) conjugated with glycol chitosan (GC) called Lf-GC which can physically interact with negatively charged alginate. Insulin molecules were entrapped during formation of nanoparticle. Here we confirmed that insulin-loaded Lf-GC-alginate nanoparticle could attenuate blood glucose level in the diabetic mouse model. Collectively, Lf-GC-alginate nanoparticle could be used as an alternative strategy for development of oral insulin formulation. |
