| 학회 | 한국재료학회 |
| 학술대회 | 2016년 가을 (11/16 ~ 11/18, 경주 현대호텔) |
| 권호 | 22권 2호 |
| 발표분야 | B. 나노화학/바이오 재료 분과 |
| 제목 | Development of multifunctional nanoreservoirs for enhanced therapeutic effect and bio-imaging |
| 초록 | Development of multifunctional nanoreservoirs for enhanced therapeutic effect and bio-imaging Min Sil Kang1,2, Jung-Hwan Lee1, Hae-Won Kim1,2,3,* 1Institute of Tissue Regeneration Engineering (ITREN), 2Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, and 3Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan 330-714, South Korea * E-mail: [email protected]; Fax: +82 41 550 3085; Tel: +82 41 550 3081 Multifunctional nanocarriers have emerged as a powerful tool for cancer theranostics. Here, we developed a hollow form of mesoporous silica with carbon dots (C-MS) to deliver high amount of therapeutic agent and to enable bio-imaging. The hollow structure was produced by templating with core nanoparticles and the carbon dots were created by processing at elevated temperature. The presence of carbon dots and luminescent properties were investigated by TEM, RAMAN, XPS, PL, and 2D excitation-emission topographical maps. The carbon dots were a few nm in size and the C-MS exhibited strong emission peaks at the various excitation wavelengths. The C-MS showed ultrahigh surface area (1087 m2/g); ~2.5-times higher than the non-hollow nanoparticle. As a result, the C-MS could load doxorubicin effectively; ~3 times higher than the non-hollow one. The doxorubicin was released sustainably (over weeks) and pH-dependently (pH 5.0 ＞ pH 7.4). When cancer cells (HeLa) were treated with the drug-loaded C-MS, apoptotic behaviors were well noticed, with a high expression of caspase-3. Moreover, when injected intratumorally in mice, the in vivo tumor growth was significantly suppressed by the drug-loaded C-MS. Overall, the results demonstrate that the developed C-MS can be used as a multifunctional delivery carrier of anticancer drug with bio-imaging ability for cancer theranostics. |
| 저자 | Min Sil Kang, Jung-Hwan Lee, Hae-Won Kim |
| 소속 | Dankook.uni |
| 키워드 | <P>Multifuctional nanocarrier; drug delivery; mesoporous; bio-imaging; </P> |
