| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
VEGF Delivery Via Polyoxalate Macrospheres Promotes Vascular Growth |
| 초록 |
Technologies to enhance angiogenesis and arteriogenesis are greatly needed in cardiovascular medicine and tissue engineering. Limited options currently exist to increase tissue vascularity in a controlled manner. The side defects such as hypotension, retinopathy, or progression of malignent tumors. A controlled released system could increase treatment efficacy, thus allowing for a lower dose of growth factor. With the extraordinary expense associated with growth factor therapy, the economic advantages are also attractive. We describe here an injectable controlled release system consisting of vascular endothelial growth factor (VEGF) encapsulated in polyoxalate microspheres (POX-MS). The majority of VEGF was released gradually over 7~10 days from the POX-MS as determined by an ELISA release kinetics study. An in vitro aortic ring bioassay was used to verify the bioactivity of VEGF-MS compared to empty MS and no treatment. This research was supported by WCU (R31-20029). |
| 저자 |
이정근, 김경희, 이지혜, 김아람, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
VEGF; Polyoxalate; Microspheres
|
| E-Mail |
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