화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터)
권호 40권 1호
발표분야 의료용 고분자 부문위원회 II
제목 Stimuli-responsive Polyelectrolyte Block Copolymer-based Micelles for Advanced Drug Delivery System
초록 Stimuli-responsive polyelectrolyte block copolymer-based micelles have received much attention for advanced drug delivery. In this study, two stimuli-responsive polyelectrolyte block copolymers of positively charged poly(N,N-dimethylaminoethyl methacrylate-block-N-isopropylacrylamide, NIPAM) and negatively charged poly(acrylic acid-block-NIPAM) were synthesized by reversible-addition-fragmentation chain-transfer radical polymerization and the temperature-triggered self-assembly was characterized. Two different polyelectrolyte block copolymers under physiological conditions formed self-assembled micelles with poly(NIPAM) block as a core and polyelectrolyte block as a shell above the transition temperature. Depending on conjugation mechanism after aminolysis, hydrophobic molecules could be controlled released. Potentially, the temperature triggered self-assembly mechanism would have a great potential for drug delivery, regenerative medicine, and tissue engineering.
저자 아그네스1, 황은영2, 임동우3
소속 1Department of Bionano Engineering, 2Hanyang Univ., 3ERICA Campus
키워드 Stimuli-responsiveness; Polyelectrolytes; Block copolymers; Self-assembly; Micelles
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