| 학회 |
한국재료학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 광주 김대중컨벤션센터) |
| 권호 |
27권 1호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
In Vitro Evaluation of Liver Decellularized Extracellular Matrix and Polysaccharides Scaffold as a Hemostatic Agent |
| 초록 |
Chitosan is well-known for its effective hemostatic properties while gelatin is a favorable biomaterial for fabricating soften and spongy formation. The purpose of this study was to examine the hemostatic properties of porous scaffold made up of chitosan/gelatin and decellularized extracellular matrix (dECM) powder obtained from porcine liver. Scaffold was fabricated under the principle of acid solubilization of decellularized extracellular matrix. Physico-mechanical characterization were performed. Results showed that the triumphal output in terms of intrinsic blood clotting was claimed in-vitro by chitosan/gelatin with dECM. Furthermore, cell toxicity evaluation with L929 cell line showed that both chitosan/gelatin and chitosan/gelatin with dECM have no obviously toxic. Thus, chitosan/gelatin with dECM scaffold can be observed as a potential absorbable hemostatic material in the prevention of hemorrhage diseases or expected bleedings in surgeries. |
| 저자 |
Chu Thanh Lan1, Byong-Taek Lee2
|
| 소속 |
1Institute of Tissue Regeneration, 2College of Medicine |
| 키워드 |
chitosan; gelatin; decellularized extracellular matrix
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| E-Mail |
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