| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Synthesis and Evaluation of biodegradable thermo-responsive gel with functional group. |
| 초록 |
ε-Caprolactone (CL) and 3-benzyloxymethyl-6-methyl-1,4-dioxane-2,5-dion (fLA), with a benzyloxymethyl group at the 3-position of the lactide, were randomly copolymerized. The methoxy polyethylene glycol MPEG-b-(PCL-ran-PfLA)] diblock copolymers were synthesized such that the PfLA content (0~15 mol%) in the PCL segment was varied. The MPEG-b-(PCL-ran-PfLA) diblock copolymers were further derivatized with benzyl group, hydroxyl group, of carboxylic acid groups. The MPEG-b-(PCL-ran-PfLA) diblock copolymer solutions exhibited sol-to-gel phase transitions upon a temperature increase which depended on both the type of functional pendant group on the PfLA and the PfLA content in the PCL segment. MPEG-b-(PCL-ran-PfLA)-COOH diblock formed gels immediately after injection into Fischer rats. The gel gradually degraded over a period of 0-6 weeks after injection. Thus, the widespread use of MPEG-b-(PCL-ran-PfLA) diblock copolymer is expected in the field of drug delievery and cell carrier. |
| 저자 |
이보근, 권두연, 박지훈, 이건희, 김재호, 김문석
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| 소속 |
아주대 |
| 키워드 |
functional monomer; copolymer; PCLA; biodegradable polymer; thermo-responsive gel
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| E-Mail |
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