| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Thrombin Activatable Peptide Conjugated Gold Nanoparticles for CT/NIRF Dual Imaging |
| 초록 |
Gold nanoparticles (AuNPs) are a unique material due to their controllable morphology, low cytotoxicity, surface plasma resonance effect and high X-ray absorption. For these reasons, AuNPs have studied and developed as an imaging probe. In this study, we developed thrombin activatable CT/NIRF imaging probe which can detect thrombosis in the blood stream. AuNPs were coated with silica layer to have stability and biocompatibility in the human body. Then thrombin activatable peptide conjugated dye (Thr-dye) was conjugated to the nanoparticle surface. When the probe interacts with thrombin, the enzyme cleaves the peptide and dequenches NIRF dyes which can detect thrombosis. Therefore, AuNP part of the probe is used as CT imaging probe and the Thr-dye dequenching system is used as NIRF imaging probe. These feasibilities of biocompatible AuNPs as CT/NIRF dual imaging probe were showed by promising results for detecting thrombosis. |
| 저자 |
정솔1, 김정연2, 김동억2, 권익찬3, 김광명3, 안철희1
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| 소속 |
1서울대, 2동국대병원, 3KIST |
| 키워드 |
Gold nanoparticle; dual imaging
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| E-Mail |
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