| 초록 |
To control a post-operative pain, a local anesthetic drug is often injected at the site of interest. However, this bolus drug injection is limited in its short residence time, thereby low bioavailability of drug. To resolve this, we fabricated the microparticles composed of a biodegradable polymer (PLGA), which were loaded with an anesthetic drug, bupivacaine. The strategy is therefore to release the drug in a sustained manner to obtain higher drug bioavailability at the injected site. The microparticles were fabricated with the O/W emulsion method, which possessed 26 μg drug per mg microparticles. Then, we evaluated their in vitro drug release profile in pH 7.4 PBS. After a burst release of 32% on day 1, the drug was slowly released for more than 20 days, the period of which was expected to be long enough to suppress a major pain after surgical treatment. |
