| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
MMP-responsive auto-clicked gold nanoparticles for tumor targeting |
| 초록 |
To manipulate size-inspired retention and clearance of nanoparticles, we herein designed a matrix metalloproteinase (MMP)-responsive nanoparticle clusters with high fidelity of size changes. AuNPs were surface-incorporated with doxorubicin by polymerization of dopamine. The incorporation of PDA-assisted doxorubicin was characterized by dynamic light scattering, electron microscopy, and spectroscopy. These nanoparticles (Dox-PDA@AuNPs) were separately decorated with 1) dibenzocyclooctyne (DBCO) moieties and 2) azido moieties and MMP-responsive PEG chains. It is anticipated that this methoxy PEG shell is peeled off when the particles reach MMP-rich environment such as aggressive solid tumors. This in turn displays the azido moieties to another Dox-PDA@AuNPs with DBCO moieties and ultimately leads to copper-free clicking of two different particles. These nanoclusters are highly retained in tumor tissues, thereby enhancing the efficacy of the combined chemo-photothermal therapy. |
| 저자 |
Hoai-Thuong D. Bui, Wei Mao, Oanh-Vu Pham-Nguyen, Jaekeun Park, Miso Lee, Wanho Cho, 유혁상
|
| 소속 |
Kangwon National Univ. |
| 키워드 |
gold nanoparticle; click reation; MMP-responsive; chemotherapy; photothermal therapy
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| E-Mail |
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