| 초록 |
A current major challenge in application of surface-enhanced Raman spectroscopy (SERS) is a method for making a substrate which has high and reproducible signal enhancement effect. Bacteriophage-based nanostructures have a potential for SERS substrate, due to its highly regular self-assembling property and diverse surface functional groups for chemical modification. In this work, bacteriophage MS2 was used as a template for making highly-ordered assembly of gold nanoparticles into a plasmonic 'nanohalo' structures. Surface lysine groups of MS2 coat proteins were functionalized with linker to regularly orient the gold nanoparticles, which makes reproducible plasmon coupling effect and hence SERS signal enhancement. |
