| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 | 22권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Gellan gum hydrogel scaffolds with PRP : New Way to Regenerate Chondrocyte from ADSCs |
| 초록 | Platelet-rich plasma (abbreviation: PRP) is blood plasma that has been enriched with platelets and it is used as a non-surgery treatment for treating cartilage damage. Especially, it promote chondrocyte and MSCs multiplication, collagenesis Aggrecan and collagen Ⅱ and trans-differentiation MSCs to Chondrocyte. Inforporation PRP with Gellan-gum, investigate the possibility of trans-differentiation of ADSCs to chondrocyte and examine the effect of PRP ratio on cartilage regeneration. PRP-GG scaffolds were analyzed using scanning electron microscope (SEM), compressive strength, MTT assay for cell proliferation, RT-PCR for expression of mRNAs and histological analysis, etc. In results, Gellan-gum loaded 20% PRP have the highest proliferation under the same conditions. Thus, the Gellan-gum with PRP scaffolds can be used as a substitute for trans-differentiation to chondrocyte. This research was supported by a grant of the Korea Health Technology R&D Project through KHIDI (HI15C2996 ). |
| 저자 | 최민정, 김한솔, 신은영, 이기원, 강길선 |
| 소속 | 전북대 |
| 키워드 | Gellangum; PRP; ADSC; Chondrocyte |
