| 초록 |
Polyethylene glycol (PEG) hydrogel is a widely used in a variety of biomedical applications and, in particular, its high printability for bioprinting. However, PEG hydrogel lacks cell viability due to the poor adhesive property. To enhance a cell viability, fibronectin derived arginine-glycine-aspartic (RGD) peptide is incorporated into PEG hydrogel. Here we developed a PEG/RGD peptide hydrogel as a bioink for 3D cell printing. A hybrid approach, employing both natural and synthetic materials, as well as printing process is the key to yield an extracellular matrix (ECM)-like scaffold with high mechanical strength, biocompatibility, and biodegradability. Through extrusion-based printing system, PEG/RGD peptide hydrogel in a layer-by-layer fashion forms a 3D porous scaffold. These cell-printed scaffold can be applied to various soft tissue regeneration such as skin, muscle, and adipose tissue. |
