| 초록 |
An ideal scaffold for bone tissue regeneration should have bone-mimicking features such as high porosity, well-interconnected pore structure, composition, biodegradability, bioactivity and biocompatibility. The conventional fabrication processes for ceramic scaffolds are replica techniques, but these processes have some shortcoming in controlling pore structural properties and reproducibility. 3D printing is a computer-aided system that can produce customized and predefined internal pore structures and external shape with high reproducibility, and is consequently considered as a new process to fabricate ideal scaffold for bone tissue regeneration. Our group suggested a novel room-temperature process to produce 3D porous bioceramic scaffolds by combining 3D printing technique with bone cement chemistry. Bioceramic scaffolds were prepared using two-step process. The first step was fabrication of the 3D porous scaffold green body using 3D printing system without hardening. The second step was cementation, which was carried out by immersing the scaffold green body in the binder solution for hardening instead of the typical sintering process. Separation of the 3D printing process and cement reaction was important to secure enough time to fabricate a 3D scaffold with various sizes and architectures under homogeneous extruding condition. This original process was highly effective in producing bioceramic scaffolds with high biofunctionality as well as good performance. |
