| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Injectable Photoreactive Azidophenyl Hyaluronic Acid Hydrogels for Tissue Augmentation |
| 초록 |
A photoreactive azidophenyl hyaluronic acid (Az-HA) derivative for tissue augmentation was prepared by direct amide bond formation between the carboxyl groups of HA and the amine groups of 4-azidoaniline. 4-Azidoaniline was introduced to the carboxyl group of hyaluronic acid that was activated by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC). The prepared Az-HA derivative was characterized by 1H NMR to measure the degree of modification. The Az-HA derivative was photo-cross-linked with varying UV irradiation times. Az-HA-20 hydrogels were formulated into injectable gels for soft tissue augmentation. Az-HA-20 formed stronger hydrogels with higher storage modulus (Pa') as UV irradiation time increased. Also, the in vitro degradation rate was lower as UV irradiation time increased. This study demonstrates that Az-HA-20 hydrogels have potential for use as injectable, biodegradable, and biocompatible hydrogels for tissue augmentation. |
| 저자 |
우희동 |
| 소속 |
(주)뉴메딕 |
| 키워드 |
Hyaluronic acid; Azidophenyl; Photoreactive; Az-HA derivative; Storage modulus (Pa')
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| E-Mail |
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