| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Synthesis of Hyperbranched Polyglycidol-b-Poly(N-isopropylacrylamide) for Temperature Sensitive Drug Delivery System |
| 초록 |
Poly(N-isopropylacrylamide) p(NIPAM) is interesting polymer that in aqueous solution it undergoes phase transition upon the lower critical solution temperature (LCST). Because LCST of p(NIPAM) is near the room temperature, it is used widely for application of smart thermoresponsive materials. N-isopropylacrylamide were polymerized by nitroxide-mediated polymerization (NMP) using hyperbranched polyglycidol-terminated 2,2,6,6-tetramethyl-1-piperidinyloxy nitroxide (TEMPO). For initiating NMP, hyperbranched polyglycidol-terminated TEMPO were synthesized via click chemistry using hyperbranched polglycidol partially modified with azide group and 4-alkynyl TEMPO previously modified from 4-hydroxy TEMPO. NMP process using N-isopropylacrylamide would be controlled by extent of modification of hydroxyl group in HBP or by the structure and molecular weight of the HBP. |
| 저자 |
허민선1, 김일2
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| 소속 |
1부산대, 2합성고분자 생물접합 하이브리드 사업단 |
| 키워드 |
Nitroxide-mediated polymerization; Click chemistry; Hyperbranched polyglycidol; Drug delivery system
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| E-Mail |
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