| 초록 |
Extracellular vesicle (EV), which plays an important role in the paracrine effect of MSCs, has been identified as an essential mediator for therapeutic effects with regenerative and anti-inflammatory capability. Although many researaches, to increase regeneration and anti-inflammatory effects by EVs attachment to the surface of biodegradable scaffold, have been reported, the comparative study for the bioactivity of EVs depending on the immobilization methods is needed. Three different coating materials, fibronectin (FN), polyethylenimine (PEI), and polydopamine (PDA), were used to graft MSC-EVs on the surface of PLGA scaffold with different bonding strengths of ligand–receptor interaction, ionic bond, and covalent bond, respectively. In vitro studies revealed that MSC-EVs grafted onto the PEI-coated surface were more successful than the other groups in boosting angiogenesis and lowering inflammation. |
