| 초록 |
Poly(L-lactic acid) (PLLA) has been used as a biodegradable vascular scaffold (BVS) material due to high mechanical property and biodegradability. However, implantation of BVS can cause inflammation, thrombosis, and restenosis. Moreover, PLLA could not detect on X-ray computed tomography (CT). To overcome these problems, we fabricated PLLA films similar to the surface of BVS and made PLLA films with two coating layers. At the first layer, the film was coated by 2,3,5-triiodobenzoic acid (TIBA) and magnesium hydroxide (MH) with poly(D,L-lactic acid) (PDLLA) for radiopaque and neutralization of acidic environment. The second layer of the films was composed of polydopamine (PDA) and then cystamine (Cys) for the generation of nitric oxide (NO) release, which is used for suppression of smooth muscle cells (SMCs) and proliferation of endothelial cells (ECs). They can surmount some problems of BVS effectively such as X-ray penetrability, inflammation, thrombosis, and hyperplasia. |
