| 초록 |
Poly(lactic-co-glycolic) acid (PLGA) has been widely used as a biomedical materials due to its great biodegradability. However, there are considerable hurdles that the degradation byproducts of PLGA cause an acidic environment of surgical site. In this study, we fabricated a PLGA scaffold combined with bovine-derived bone extracellular matrix (bECM) and magnesium hydroxide [Mg(OH)2] to reduce anti-inflammation, and to enhance osteoconductivity. Recently, many researchers are using mesenchymal stem cells (MSCs) for bone tissue engineering. Bone morphogenetic protein-2 (BMP2) is known for osteogenic differentiation of MSCs. However, since the initial burst of BMP2 has several side effects, we induced the sustained release of BMP2 by forming nanocomplex (NC) with polydeoxyribonucleotide (PDRN) enhancing angiogenesis by stimulating adenosine A2A receptor. In conclusion, the hybrid scaffold immobilized with NC using hfMSCs improved angiogenesis, anti-inflammation, and osteogenesis. |
