| 초록 |
We report a novel phenothiazine appended porphyrin derivative (PTZP) as a fluorescent probe for the detection of hypochlorite (ClO-). Hypochlorite is one of important reactive oxygen species (ROS), which boost the immune system of the body, while excessive hypochlorite can cause a variety of diseases. PTZP consists of mainly three components, phospholipid-like long alkyl chains, porphyrin fluorescent body, and electron-accepting phenothiazine (PTZ). In THF/H2O (9:1 v/v), ClO- effectively oxidizes sulfur atom of phenothiazine by which electron accepting ability of PTZ would be demaged, as a result emission of the porphyrin fluorescence was not quenched. ·O2-, ·OH, 1O2, H2O2, NO, ONOO-, TBHP, and TBO· were added to the probe to examine the selectivity. These molecules did not oxidize the phenothiazine moiety and no enhanced fluorescence was observed. |
