| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Anticoagulant activity of heparin analogues on fibrin formation characterized by QCM-Z and AFM |
| 초록 |
The anticoagulant function of heparin has been well known as heparin plays an important role by accelerating inhibition of fibrin formation more than 1,000 folds. After the role of heparin was highlighted, heparin-like materials have been paid attention to improve blood-compatibility of biomaterials. In the present study we prepared sulfonated PEO and sulfonated chitosan as the heparin-like materials and their anticoagulant activities were studied quantitatively by using QCM-Z and AFM. QCM-Z technique allowed simultaneous measurements of the mass change and the viscoelastic property of fibrin layers under various conditions. AFM was used to characterize the final morphology of polymerized fibrin layers. |
| 저자 |
정효숙, 김자영, 태기융, 김영하
|
| 소속 |
광주과학기술원 |
| 키워드 |
sulfonated PEO; sulfonated chitosan; heparin; anticoagulant; fibrin; QCM-Z; AFM
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| E-Mail |
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