| 초록 |
Glaucoma is a risky eye disease causing irreversible vision loss by inducing continuous damage to optic nerve cells. The main cause of glaucoma is increased intraocular pressure (IOP), so it can be treated by lowering IOP. A variety of therapeutics have been developed for lowering IOP. However, new medicine needs to be developed due to increased tolerance and side effects of previous treatments. Nitric oxide (NO) is a gasotransmitter regulating cellular functions in human body. NO can increase fluid flow of eye via conventional pathway and decrease the IOP based on its cell relaxation effect. In this study, we developed NO-releasing polydiazeniumdiolate (NOP) by ethanol and sodium methoxide under high pressure of NO gas. Based on the stability of multiple carbon-bound NO donor moieties, NOP efficiently provided NO with 4.8 μmol/mg for 5 days. Based on the accurate analysis of NO release, we discovered maximum cell relaxation and IOP lowering performance of NOP via in vivo study. |
