| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Characteristic Analysis and Release Behavior of Olmesartan-loaded Polyoxalate Microspheres |
| 초록 |
Polyoxalates(POX) is biodegradable and biocompatible polymer. Olmesartan is used alone or in combination with other medications to treat high blood pressure in adults and children above 6 years. The purpose of this study was to prepare and evaluate the characteristic of olmesartan-loaded microspheres from various preparation methods. Olmesartan-loaded POX microspheres were characterized for the drug load, out/inner surface morphology and in vitro drug release. Physicochemical characters and morphology of prepared microspheres were evaluated by Fourier transform infrared (FT-IR), X-ray diffraction (XRD), differential scanning calorimeter (DSC) and scanning electron microscopy (SEM). Result showed that the prepared microspheres were comprised of POX with valsartan encapsulated within the microspheres. Also, the degradation of microspheres by SEM and the drug release were obtained from in vitro test for 15 days. This work was supported by the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
신재훈, 김수영, 김창현, 정현기, 송야성, 김은영, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
olmesartan; in vitro; release; POX; O1/O2/W.
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| E-Mail |
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