| 초록 |
In this study, a simple micropatterning method of cells on a non-biological substrate using ion beam lithography is described. Cell-compatible poly(vinyl alcohol) (PVA) thin films spin-coated on a non-biological polystyrene (PS) surface were selectively irradiated through a pattern mask and then developed with water to form PVA patterns. The surface properties of PVA-patterned PS surface were investigated in terms of the wettability, chemical composition, and surface morphology. The result of the in-vitro cell culture revealed that cells were strongly adhered and proliferated onto the PVA surface, resulting in the formation of clear micropatterns of cells. This cell behavior can be attributed to the difference in the wettability between the PVA and PS surfaces. |
