| 초록 |
Liposomes have been extensively investigated as drug delivery vehicles. Alendronate (AL), one of bisphosphonate drugs, inhibits osteoclastic bone resorption. A major problem in the clinical use of bisphosphonates is their poor intestinal absorption. We prepared various liposomal AL formulations and characterized their physicochemical properties as well as in vitro gastrointestinal stability for the purpose of enhancing intestinal absorption of AL. Mean particle size of the prepared liposomes was approximately 110 nm. Stability of AL-loaded conventional liposomes and PEG-liposomes were investigated by measuring size of the liposomes in gastric sol‘n, intestinal sol’n and bile extract sol‘n. In order to investigate the effects of AL-loaded PEG-liposomes on intestinal permeability, we performed PAMPA (parallel artificial membrane permeability assay) of the prepared liposomes containing various absorption enhancers. |
