| 초록 |
Growing evidence show that three-dimensional (3D) environment reveals fundamental mechanisms of cell function and that 3D culture system in vitro can facilitate the understanding of structure–function relationship in normal and pathological conditions. The development of hydrogels offers new opportunities not only for tissue engineering but also for setting up culture systems in vitro that recapitulate the 3D organization and the differentiated function of these tissues. Particularly, thermo-sensitive hydrogels are of great interest in drug delivery, cell encapsulation, and tissue engineering. This study aims to develop a injectable, superporous hydrogel system based on poly(N-isopropylacrylamide) hydrogel, that can serve as scaffolds promoting bone repair and regeneration. We prepared loosely crosslinked poly(N-isopropylacrylamide-co-vinyl phosphonic acid) hydrogels and investigated their physicochemical characteristics and cell growth in the P(NIPAAm-VPAc) hydrogel system. |
