| 초록 |
Magnetic polymer particles have been used extensively in several biomedical applications, such as magnetic cell separation, enzyme immunoassay, targeted drug delivery and diagnostics, etc. In this study, magnetite-contained poly(ethylene glycol-b-ε caprolactone) nano-particles were prepared by emulsion method. As a magnetic material, magnetite (Fe3O4) was used with low toxicity and well tolerance in the human body. Also, biodegradable polymer was used poly (ε-caprolactone) providing biodegradability, high biocompatibility, drug compatibility, and permeability. The magnetic particles coated with biodegradable polymer can make it possible to direct the particles to the specified location by means of external magnetic fields. This, in turn, would reduce the side-effects of the drug because its level in the general circulation is lowered. The polymer coated around magnetite would play the role of transporting the drug and releasing it during its biodegradation. Morphology, size as well as magnetite loading efficiency of prepared magnetic particles, were characterized to examine the possible use as a magnetic drug carrier. |
