| 초록 |
Macrocycles are interesting molecules because their topological features and constraned properties significantly affect their chemical, physical, biological, and self-assembling properties. In this study, we synthesized unique macrocyclic peptides composed of both an α-helix and a polyproline segment and analyzed their conformational properties. We found that the molecular stiffness of the rod-like polyproline segment and the relative orientation of the two different helical segments strongly affect the efficienty of the macrocyclization. Conformational analyses showed that both α-helix and the polyproline II helix coexisted within the macrocyclic peptides and that the polyproline segment exerts significant effect on the overall helical stability and consofrmation of the α-helical segment. |
