| 초록 |
To study bio-related surfaces it is essential to know the identification, concentration and spatial distribution of unknown molecules from sample surfaces. In particular, quantitative analysis of molecules existing on the surface is crucial for using bio-surfaces for future applications. In this talk, I will suggest that the ToF-SIMS technique can play an important role in the quantitative analysis of bio-surfaces. As our model systems, the amine density of plasma-polymerized ethylene diamine (PPEDA) surface and the streptavidin concentration which interacted with the biotin on the dendrimer monolayer were quantitatively studied by ToF-SIMS in conjunction with UV-visible spectrometry and SPR techniques, respectively. In addition to these quantitative studies, micropatterns of PEG, streptavidin and human epidermal carcinoma A431 cells were successfully imaged, as received and without any labeling, using for the first time the cluster Au3+and Bi3+ion beams in TOF-SIMS. |
