| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
A Simple Host-Guest Assembly for High-Resolution Magnetic Resonance Imaging of Microvasculature |
| 초록 |
Magnetic resonance angiography (MRA) is an important imaging technique that can be used to identify and characterize various types of vascular diseases. However, currently used molecular contrast agents are unsuitable for MRA due to the short intravascular retention time, the whole-body distribution, and the relatively low contrast effect. In this study, we developed a vascular analysis contrast agent (i.e., VasCA) for MRA, which is a simple and biocompatible 1:1 host-guest assembly of PEGylated β-cyclodextrin and gadolinium chelate with renal clearable size and high relaxivity (r1 = 9.27 mM-1 s-1). In vivo, VasCA circulated in the blood vessels much longer (4.3-fold increase) than gadoterate meglumine (Dotarem) and was mainly excreted by the renal system after i.v. injection. This feature of VasCA allows characterization of tumor microvasculature as well as visualization of small vessels in the brain and body organs. Our study provides a useful tool for diverse MRA applications. |
| 저자 |
황윤서, 김주희, 안예린, 이성규, 임국희, 최현우, 유동원
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| 소속 |
서울대 |
| 키워드 |
blood-pool contrast agents; magnetic resonance imaging; microvasculature; renal clearance; β-cyclodextrin; gadolinium chelate
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| E-Mail |
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