| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
A Novel Strategy for Cancer Immunotherapy by Foreignizing Tumor cells Using a Polymeric Conjugate |
| 초록 |
Cytotoxic T lymphocytes (CTLs) play important roles in immunological rejection in cancer immunotherapy. However, most tumors are not rejected by the immune system because they have self-antigens, which are not recognized by CTLs. In this study, we hypothesized that “foreignizing tumor cells” by delivering foreign antigen into the tumor cells might result in immunological rejection by CTLs. We prepared a polymeric conjugate including ovalbumin (OVA) as a foreign antigen and hyaluronic acid as a tumor-targeting ligand. It was effectively taken up by TC-1 cells and caused high OVA peptide presentation on the cellular surface. Furthermore, it was effectively accumulated into tumor site after I.V. injection, followed by substantial inhibition of tumor growth in mice model which is immunized with a vaccinia virus expressing OVA. These results demonstrated that the polymeric conjugates bearing foreign antigens are promising cancer immunotherapeutic agents by foreignizing tumor cells. |
| 저자 |
신정민1, 윤홍열1, 이민창1, 권승리1, 이영호2, 김태우2, 박재형1
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| 소속 |
1성균관대, 2고려대 |
| 키워드 |
Polymeric conjugate; Cancer immunotherapy; Antigen delivery; Hyaluronic acid; Foreignization
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| E-Mail |
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