| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Hypoxia-triggered drug deliveryusing carboxymethyl dextran-based self-assembled nanoparticles |
| 초록 |
In this study, we attempted to prepare hypoxia-responsive nanoparticles (HR-NPs) that facilitate rapid release of drugs at hypoxic tumor tissue, resulting in enhanced therapeutic efficacy. To prepare hypoxia-responsive amphiphilic conjugates, a hydrophobic 2-nitroimidazole (NI) derivative was conjugated to the backbone of hydrophilic carboxymethyl-dextran through amide formation. Doxorubicin was encapsulated into the hydrophobic core of HR-NPs by the emulsion method. Due to the high sensitivity to hypoxia of NI derivative, the drug release rate of HR-NPs remarkably increased under the hypoxic condition. In addition, HR-NPs were selectively accumulated at the hypoxic tumor tissues after their systemic administration into the tumor-bearing mice. Overall, HR-NPs could be promising drug carriers for selective delivery of drugs into hypoxic cells. |
| 저자 |
Thavasyappan Thambi, 손소영, 윤홍열, 이민창, 박재형
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| 소속 |
성균관대 |
| 키워드 |
hypoxia; drug delivery; nanoparticles; bioreduction
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| E-Mail |
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