| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Development of an artificial α-helical polypeptide adjuvant for dendritic cell activation through cGAS-STING pathway. |
| 초록 |
The purpose of the development of the artificial alpha-helical polypeptide adjuvant (PA) is to deliver antigen to dendritic cells (DCs). Immature DCs have high antigen uptake capacity and mature at the time of antigen uptake. When we deliver antigen-PA nanoparticles, DCs represent higher expression levels of CD40 and CD86. CD40 and CD86 are DCs cell markers that increase the stimulation of T cells. The cationic alpha-helical polypeptide PA1 (Poly((1-(2-(2-hydroxyethoxy)ethyl)piperazinyl)pentyloxy benzyl-L-lysine) and PA2 (Poly(1-aza-18-crown-6)pentyloxy benzyl-L-lysine) with model antigen ovalbumin (OVA) nanoparticles show higher DC activation capacity than chitosan (CS)-OVA nanoparticle, which is known to have an adjuvant effect. |
| 저자 |
김문식, 이대용, 김유천
|
| 소속 |
한국과학기술원 |
| 키워드 |
Dendritic cell; cGAS-STING pathway; synthetic polypeptide; synthetic adjuvant
|
| E-Mail |
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