| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
pH-activated helical polypeptide eliciting selective pro-apoptotic activity |
| 초록 |
Atificial cationic helical polypeptides were endowed with the enhanced cell-penetrating characteristic. However, the cell-penetrability was not converted by cellular environmental changes, resulting in nonspecific binding. Herein, our group suggested that pH-sensitive anion-donating group were introduced in the helical polypeptide to simultaneously attain tumor targeting and pro-apoptotic activity. The mitochondria-disrupting helical polypeptide undergoing pH-dependent conformational transitions selectively bound to cancer cells and then, destabilized the mitochondrial membranes, thereby provoking apoptosis. This work provides a promising peptide therapeutic systems for cancer therapy. |
| 저자 |
이대용1, 이수환2, 나유진2, 노일구1, 하종훈1, 유지상1, 윤채옥2, 김유천1
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| 소속 |
1한국과학기술원, 2한양대 |
| 키워드 |
pH-activated helix; pro-apoptosis; mitochondria; cancer therapy
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| E-Mail |
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