| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
A DOPA-Fe3+ gelatin hydrogel as a tissue adhesive |
| 초록 |
Tissue adhesives have been widely used in clinics as wound closure devices, hemostatic agents, and tissue sealants to control blood loss and promote tissue healing. Here we present human gelatin tissue adhesive hydrogels prepared by enzyme-mediated biosynthesis of DOPA and Fe3+ ion crosslinking. The human adipose derived gelatin had highly purified protein content and abundant tyrosine residue. The tyrosine residues in gelatin were simply converted to DOPA by tyrosinase reaction and the DOPA-modified gelatin formed an elastic, sticky hydrogel with the addition of Fe3+ ions. These DOPA-Fe3+ gelatin hydrogels showed excellent hemostatic ability in the in vivo hemorrhaging liver rat model as well as good mechanical properties, stability, biocompatibility in vitro. The human gelatin hydrogels prepared by a simple and bio-inspired method would be useful as a tissue adhesive for a variety of surgical applications. |
| 저자 |
김준성, 최영찬, 이인재, 윤화인, 최지숙, 조용우
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| 소속 |
한양대 |
| 키워드 |
gelatin; tissue adhesive; DOPA; hydrogel
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| E-Mail |
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