| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Preparation and release behavior of Ipriflavone-loaded PLGA scaffold for tissue engineered bone |
| 초록 |
The regeneration of bone tissue is an ambitious goal in orthopaedic surgery for healing large bone defects secondary to tumor or trauma, and for treating delayed unions or non-unions. Recently, bone tissue engineering has become a possible alternative strategy to regenerate bone. In this study, we developed the novel IP loaded poly(L-lactide-co-glycolide)(PLGA) scaffolds for the application of the tissue engineered bone. IP/PLGA scaffolds were prepared by solvent casting/ice leaching method and were characterized by porosimeter, SEM. The release profiles of Ipriflavone were examined using pH 7.4 PBS by HPLC (for 84 days at 37 °C). Cellular viability and Osteogenic differential were assayed by CCK-8, ALP activity. The release of IP in vitro was more prolonged over 80 days. Formation of bone tissue was better IP/PLGA hybrid scaffold than control. As a result of this study, It seems that ipriflavone plays an important role for bone induction in IP/PLGA scaffolds. |
| 저자 |
소정원1, 윤선중1, 김순희1, 백미옥1, 임지예1, 최진희1, 강길선1, 이해방2
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| 소속 |
1전북대, 2한국화학(연) |
| 키워드 |
PLGA 지지체 |
| E-Mail |
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