| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
대학원생 구두발표 (영어발표, 발표15분) |
| 제목 |
COPPER-FREE CLICKED NANOCLUSTERS OF GOLD NANOPARTICLES AND QUANTUM DOTS FOR IN VIVO REAL-TIME IMAGING AND TUMOR SENSING. |
| 초록 |
Nowadays, fabrication of biosensors for cancer detection, monitoring of angiogenesis or cancer metastasis and cancer imaging holds vast potential. In this study, a biosensor based on clustering of matrix metallopeptidase (MMP) enzyme responsive gold nanoparticles (AuNP) and quantum dots (QD) by azide-alkyne copper-free click reaction was proposed. Briefly, AuNP were surface-decorated with two different types of poly(ethylene glycol) (PEG). Carboxylate-PEG was used to conjugate with MMP cleavable peptide (MMP CP) and azide-PEG was used for azide-alkyne copper-free click reaction between AuNP and alkyne decorated QD to form clusters at tumor site. As a result, FRET occurred during the clustering process and fluorescence intensity of QD was quenched. Thereby, our MMP-responsive nanoclusters could be used for in vivo real-time imaging as well as sensing tumor-specific environments. |
| 저자 |
Vu Nguyen Oanh Pham, 신지운, Wei Mao, 이주원, 박재근, 이미소, 조완호, 유혁상
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| 소속 |
강원대 |
| 키워드 |
Gold nanoparticles; quantum dots; biosensors; copper-free click reaction; FRET
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| E-Mail |
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