| 학회 |
한국공업화학회 |
| 학술대회 |
2006년 봄 (05/12 ~ 05/13, 전북대학교) |
| 권호 |
10권 1호 |
| 발표분야 |
생물공학 |
| 제목 |
Identification and Characterizarion of Rv3281 as a Novel Subunit of a Biotin-Dependent Acyl-CoA Carboxylase in Mycobacterium tuberculosis H37Rv |
| 초록 |
Mycobacterium tuberculosis produces a large number of structurally diverse lipids generated from the carboxylation products of acetyl-CoA and propionyl-CoA. A biotin-dependent acyl-CoA carboxylase was purified from M. tuberculosis H37Rv and acyl-CoA carboxylase activity was successfully reconstituted for the first time from purified subunits of the acyl-CoA carboxylase of M. tuberculosis. The reconstituted α3-β5 showed higher activity with propionyl-CoA than with acetyl-CoA and the addition of the ε-subunit stimulated the carboxylation by 3.2 and 6.3-fold respectively. |
| 저자 |
오태진 |
| 소속 |
선문대 |
| 키워드 |
Mycobacterium tuberculosis; carboxylase; Rv3281
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| E-Mail |
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