| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Long Acting Hyaluronate Exendin 4 Conjugate for the Treatment of Type 2 Diabetes |
| 초록 |
Despite clinical exploitation of exendin 4 for the treatment of type 2 diabetes, the short half-life of exendin 4 has limited the wide applications. In this work, hyaluronate (HA) exendin 4 conjugate was successfully developed using Michael addition chemistry between vinyl sulfone modified HA (HA-VS) and thiolated exendin 4. The exendin 4 content could be controlled in the range of 5~30 molecules per single HA chain with bioconjugation efficiency higher than 90%. The conjugation resulted in about 20 times improved in vitro serum stability maintaining the biological activities of exendin 4. HA exendin 4 conjugates showed excellent glucose-lowering capabilities in type 2 db/db mice up to 3 days after a single subcutaneous injection. Insulin immunohistochemical analysis confirmed the improved insulinotropic activity of HA exendin 4 conjugates. HA exendin 4 conjugates will be investigated further as a twice a week dosage form for clinical applications. |
| 저자 |
오은주1, 공지현1, 채수영2, 이강춘2, 한세광1
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| 소속 |
1POSTECH, 2성균관대 |
| 키워드 |
Hyaluronic acid; Exendin-4; Conjugation; Drug delivery; Type 2 diabetes
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| E-Mail |
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