| 초록 |
Particulate systems, such as liposomes, micro- or nanoparticles, have attracted a great deal of attention as possible delivery forms for unstable active agents. However, liposomes are liable to be destructed by the pH and bile salts. To minimize the disruptive influences, the formation of a polymeric membrane around the liposome has been studied. In this research, the nano-sized liposomes were prepared using the phosphatidyl choline and their surface was coated with hydrophilic polymer such as a poly(vinyl alcohol) to improve the stability of the liposomes. To investigate the encapsulation into the liposome, the calcein was used as a model agent. The encapsulation efficiency and stability of polymer-coated liposomes were investigated under various medium conditions. The release behavior revealed that the particle size and entrapment efficiency of liposomes significantly depended on the concentration of coated material. |
