| 초록 |
Hydroxyapatite (HA)-containing polymers have been proposed as the candidates for improving the biological properties of bone cements. Poly(3-hydroxy butylate-co-hydroxy valerate) (PHBV) is part of a large family of barterial polyesters called poly(hydroxyalkanoates). PHBVs are being developed and commercialized as ideal candidates for the substitution of non-biodegradable polymeric materials in commodity applications because of their biodegradability and easy processability. In this study, PHBV/HA nanofibers were fabricated by electrospinning a mixed solution of HA, PHBV and 2,2,2-trifluoroethanol (TFE). PHBV/HA nanofibers were characterized by SEM, TEM, XRD, FT-IR and ESCA. The potential of this nanofiber for use as bone scaffolds was assessed by osteoblastic cell (MC3T3-E1) in terms of adhesion, proliferation and differentiation. |
