| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.105 |
| 발표분야 | 기능성 고분자 |
| 제목 | pH & thermo-sensitive block copolymer hydrogels |
| 초록 | Biodegradable polymer devices show great potential for a variety of therapeutic applications including controlled release of proteins and water-insoluble drugs and polymer scaffolds for tissue engineering. Among them, the injectable hydrogels have been interested in the drug delivery field.1-2 In this study, we synthesized the pH & themo-sensitive block copolymer for the injectable matrix of drug. The triblock (PCLA-PEG-PCLA) copolymers were synthesized through a ring-opening copolymerization of D,L- lactide and ε-caprolactone with PEG(poly (ethylene glycol)) as an initiator. The PEG/PCLA and CL/LA ratio were controlled by feed ratio, respectively. The coupling reaction of the block copolymer and oligo-sulfamethazine with carboxyl end group as pH moiety was done by the 1,3-Dicyclo-hexylcarbodiimide(DCC). The triblock copolymer coupled with oligo-sulfamethazine (OSM-PCLA-PEG-PCLA-OSM) is certificated by GPC & NMR. OSM-PCLA-PEG-PCLA-OSM hydrogels are shown the sol-gel phase transition with pH & temperature change. The block copolymer hydrogel is not shown the gel with increasing the temperature above pH 8.0. But, it is shown the sol-gel transition with increasing the temperature below pH 8.0. Also, as the pH of hydrogel was decreased, the temperature region of gel state was increased. The triblock copolymer hydrogel (pH 8.0) flows at the room temperature (20℃). As this solution is injected into the buffer solution (pH 7.4, 37℃), the triblock copolymer hydrogel forms the gel in the buffer solution (pH 7.4, 37℃). But, triblock copolymer hydrogel doesn’t form the gel in the buffer solution (pH 8.0, 37℃). These hydrogel is used as a matrix for sustained release of the hydrophobic drug. Fig. 1. Sol-gel phase diagram of PCLA-PEG-PCLA & OSM-PCLA-PEG-PCLA-OSM hydrogels. References 1. Byeongmoon Jeong, Doo Sung Lee, You Han Bae and Sung Wan Kim , Nature, 388, 860-862 (1997) 2. Doo Sung Lee, Myung Seob Shim, Sung Wan Kim, Hyunjung Lee, Insun Park and Taihyun Chang, , Macromolecular Rapid Communications, 22, 587-592 (2001). |
| 저자 | 심우선, 이두성 |
| 소속 | 성균관대 |
| 키워드 | pH sensitivie; thermo-sensitive; hydrogel |
