| 초록 |
Multi-responsive controlled release of drug delivery system is highly desirable in biomedical application due to therapeutic efficiency. Mesoporous silica nanoparticles (MSNs) with stimuli-responsive gate keeper have shown promise in the area of drug delivery because of high surface area, large pore volume, and good biocompatibility. However, they need complicated synthesis procedures in response to external physical or chemical stimuli. Here, we report facile method for synthesizing multi-responsive gatekeepers and gel composites through metal-phenolic network. Metal-phenolic complex on MSNs showed not only efficiently entrapped guest molecules without sustain release but also confirmed pulsatile release of guest molecules under ultrasound and electrical input due to robust metal-phenolic network. This study realized efficient platforms for active-type drug-delivery applications based on transdermal patches and implantable gels with remotely controllable release characteristics. |
