| 초록 |
Pseudomonas aeruginosa has developed resistance against flomoxef sodium, isepamicin and cefpiramide. Therefore the antibacterial activity and synergistic effects of the amphipathic-derived P5-18mer antimicrobial peptide were tested against pathogens associated with cholelithiasis that have developed resistance against commonly used antibiotics. P5-18mer peptide displayed strong activity against pathogens, but it did not exert cytotoxicity against the human keratinocyte cell.Moreover, these peptides has a rapid microbicidal effect on flomoxef sodium, isepamicin and cefpiramide-resistant strains of P. aeruginosa. Therefore, these peptides may be used as a lead drug for the treatment of acquired pathogens from patients with cholelithiasis who are affected with antibiotic-resistant bacteria. |
