| 초록 |
In the antitumor immune response, damage-associated molecular pattern molecules (DAMPs) have a key role in stimulating immune cells. Notably, high mobility box group-1 (HMGB1) is crucial to mature antigen-presenting cells, priming T cells toward tumor rejection. However, exploiting HMGB1 in cancer immune therapy has remained a conundrum, as it readily undergoes inactivation by caspase-3 during apoptosis. Here we report a stabilized nanobubble (NB) that embedding perfluorocarbon. The acoustic cavitation effect of NBs upon ultrasound exposure triggers inflation of PFP, facilitating cell- membrane rupture resulting release of intact HMGB1. Accordingly, the extracellular HMGB1 provokes the maturation of dendritic cells. |
